%0 Journal Article
%T Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives
%A Yahia Nasser Mabkhot
%A Nabila Abdelshafy Kheder
%A Ahmad M. Farag
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18044669
%X A series of thieno[2,3- b]thiophene moiety-containing bis-cyanopyrazoles 5a¨C c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3- b]thiophene-2,5-diyl)bis(3-acetyl-1-(4-chlorophenyl)-1 H-pyrazole-4-carbonitrile) ( 5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin B against Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli.
%K thieno[2
%K 3-b]thiophene
%K nucleophilic addition
%K hydrazonoyl halides
%K bis-pyrazole
%K antimicrobial activity
%U http://www.mdpi.com/1420-3049/18/4/4669