%0 Journal Article
%T Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh
%A Rosalind Pei Theng Kim
%A Vicky Bihud
%A Khalit bin Mohamad
%A Kok Hoong Leong
%A Jamaludin bin Mohamad
%A Fasihuddin bin Ahmad
%A Hazrina Hazni
%A Noraini Kasim
%A Siti Nadiah Abdul Halim
%A Khalijah Awang
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18010128
%X Eleven compounds:goniomicin A ( 1), goniomicin B ( 2), goniomicin C ( 3), goniomicin D ( 4), tapisoidin ( 5), goniothalamin ( 6), 9-deoxygoniopypyrone ( 7), pterodondiol ( 8), liriodenine ( 9), benzamide ( 10) and cinnamic acid ( 11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin ( 6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC 50value of 64.17 ¡À 5.60 ¦ÌM. Goniomicin B ( 2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC 50 of 0.207 ¦ÌM.
%K Goniothalamus tapisoides
%K goniomicins A¨CD
%K tapisoidin
%K cytotoxicity
%K antioxidant activity
%U http://www.mdpi.com/1420-3049/18/1/128