%0 Journal Article
%T Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro
%A Zhi-Jun Dai
%A Bao-Feng Wang
%A Wang-Feng Lu
%A Zhi-Dong Wang
%A Xiao-Bin Ma
%A Wei-Li Min
%A Hua-Feng Kang
%A Xi-Jing Wang
%A Wen-Ying Wu
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18010934
%X Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don ( S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression.
%K hepatoma
%K Scutellaria barbata
%K invasion
%K metastasis
%K matrix metalloproteinase
%U http://www.mdpi.com/1420-3049/18/1/934