%0 Journal Article
%T Preparation, Purification and Regioselective Functionalization of Protoescigenin¡ªThe Main Aglycone of Escin Complex
%A Mariusz M. Gruza
%A Kamil Jatczak
%A Bogdan Zagrodzki
%A Marta £¿aszcz
%A Katarzyna Koziak
%A Maura Mali¨½ska
%A Piotr Cmoch
%A Tomasz Giller
%A Oliwia Zegrocka-Stendel
%A Krzysztof Wo£¿niak
%A Grzegorz Grynkiewicz
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18044389
%X A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture¡ªprotoescigenin¡ªwas isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di- O,O-isopropylidene derivative in a validated large scale laboratory process.
%K escin
%K protoescigenin hydrates
%K protoescigenin diacetonide
%K polymorphism
%K X-ray crystallography
%U http://www.mdpi.com/1420-3049/18/4/4389