%0 Journal Article
%T Nuclear accumulation of ¦Â-catenin and forkhead box O3a in colon cancer: Dangerous liaison
%A Wolfgang Link
%J World Journal of Biological Chemistry
%D 2012
%I Baishideng Publishing Group Co. Limited
%R 10.4331/wjbc.v3.i9.175
%X The WNT/¦Â-catenin and phosphoinositide 3-kinase (PI3K/AKT) signaling cascades both have been implicated in the formation and progression of colorectal cancer. Oncogenic PI3K/AKT signaling suppresses the activity of forkhead box O3a (FOXO3a) transcription factor through phosphorylation leading to its nuclear exclusion. Inhibition of the PI3K/AKT signaling by PI3K or AKT inhibitors results in the translocation of FOXO3a to the nucleus, and is considered to be a promising therapeutic strategy for many cancers including colon cancer. Now, however, a new study in Nature Medicine has revealed a nuclear interaction of ¦Â-catenin with FOXO3a as a promoter of metastatic progression in colon cancer. The work has important implications for the treatment of colon cancers, suggests a companion biomarker strategy to enable a personalized medicine approach, and offers an alternative therapeutic strategy to overcome resistance to PI3K and AKT inhibitors.
%K Colon cancer
%K ¦Â-catenin
%K Forkhead box O3a
%K Metastasis
%K Drug resistance
%K PI3k/AKT inhibitors
%K Tankyrase inhibitors
%K Personalized medicine
%K Xenopatient
%U http://www.wjgnet.com/1949-8454/full/v3/i9/175.htm