%0 Journal Article
%T Effects of Freshwater Clam Extract Supplementation on Time to Exhaustion, Muscle Damage, Pro/Anti-Inflammatory Cytokines, and Liver Injury in Rats after Exhaustive Exercise
%A Kuo-Chin Huang
%A Wen-Tien Wu
%A Fwu-Lin Yang
%A Yi-Han Chiu
%A Tai-Chu Peng
%A Bang-Gee Hsu
%A Kuang-Wen Liao
%A Ru-Ping Lee
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18043825
%X The potent anti-inflammatory activities and tissue-protective effects of freshwater clams ( Corbicula fluminea) have been well reported. The aim of this study was to determine the effects of freshwater clam extract (FCE) supplementation on time to exhaustion, muscle damage, pro- and anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise. Thirty-two rats were divided into four groups: sedentary control (SC); SC group with FCE supplementation (SC+FCE); exhaustive exercise (E); and E group with FCE supplementation (E+FCE). The SC+FCE and E+FCE groups were treated with gavage administration of 20 mg/kg for seven consecutive days. Blood samples were collected for the evaluation of biochemical parameters. The cytokine levels of TNF-¦Á and IL-10 were also examined. Twenty-four hours after exhaustive exercise, the rat livers were removed for H & E staining. The FCE supplementation could extend the time to exhaustion in exercised rats. The levels of CPK, LDH, AST, ALT, lactate, TNF-¦Á and H & E stains of the liver injury were significantly decreased in the E+FCE group, but the blood glucose and IL-10 were significantly higher in comparison with the E group. This study suggests that FCE supplementation may improve endurance performance and reduce exercise-induced muscle damage, inflammatory stress and liver injury.
%K Corbicula fluminea
%K anti-inflammatory
%K endurance performance
%K blood glucose
%U http://www.mdpi.com/1420-3049/18/4/3825