%0 Journal Article
%T A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
%A Jun He
%A Guang Ouyang
%A Zhixiang Yuan
%A Rongsheng Tong
%A Jianyou Shi
%A Liang Ouyang
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18055142
%X An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an ¦Á-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione . The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
%K multicomponent reactions
%K 1
%K 3-dipolar cycloaddition
%K azomethine ylide
%K dispirooxindole
%U http://www.mdpi.com/1420-3049/18/5/5142