%0 Journal Article
%T A Facile Synthesis of Fully Protected meso-Diaminopimelic Acid (DAP) and Its Application to the Preparation of Lipophilic N-Acyl iE-DAP
%A Yukako Saito
%A Yuichi Yoshimura
%A Hideaki Wakamatsu
%A Hiroki Takahata
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18011162
%X Synthesis of beneficial protected meso-DAP 9 by cross metathesis of the Garner aldehyde-derived vinyl glycine 1b with protected allyl glycine 2 in the presence of Grubbs second-generation catalyst was performed. Preparation of lipophilic N-acyl iE-DAP as potent agonists of NOD 1-mediated immune response from 9 is described.
%K protected meso-diaminopimelic acid
%K N-acyl iE-DAP
%K cross metathesis
%U http://www.mdpi.com/1420-3049/18/1/1162