%0 Journal Article
%T Synthesis and Cytotoxicity of Novel 10-Substituted Dihydroartemisinin Derivatives Containing N-Arylphenyl-ethenesulfonamide Groups
%A Yajing Liu
%A Zijian Liu
%A Jiyue Shi
%A Huimin Chen
%A Bin Mi
%A Peng Li
%A Ping Gong
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18032864
%X The manuscript describes the synthesis of 10-substituted dihydroartemisinin derivatives containing N-aryl phenylethenesulfonamide groups and their in vitro anti-tumor activities against the HT-29, MDA-MB-231, U87MG, H460, A549 and HL-60 cancer cell lines and the normal WI-38 cell line. Most tested compounds showed enhanced cytotoxic activities and good selectivity toward the MDA-MB-231, HT-29 and HL-60 cell lines, with IC 50 values in the single-digit ¦ÌM range as compared with dihydroartemisinin (DHA), and all of them displayed less toxicity towards WI-38 cells. Among them, compounds 3c and 6c with trifluoromethoxy groups on the N-phenyl ring were found to be most active compounds against the six tested cancer cell lines.
%K 10-substituted dihydroartemisinin derivatives
%K synthesis
%K anti-cancer
%U http://www.mdpi.com/1420-3049/18/3/2864