%0 Journal Article
%T Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine
%A Ivana M. Marzano
%A Marina S. Franco
%A Priscila P. Silva
%A Rodinei Augusti
%A Geandson C. Santos
%A Nelson G. Fernandes
%A M£¿nica Bucciarelli-Rodriguez
%A Edmar Chartone-Souza
%A Elene C. Pereira-Maia
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18021464
%X A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl 3(C 11H 11N 3O 2S) 3]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC 50 value of 44 ¦ÌM whereas the free ligand has no effect up to 100 ¦ÌM.
%K Bi(III) complex
%K sulfapyridine
%K X-ray structure
%K antimicrobial activity
%K cytotoxic activity
%U http://www.mdpi.com/1420-3049/18/2/1464