%0 Journal Article
%T Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
%A Tran Dinh Thang
%A Ping-Chung Kuo
%A Guan-Jhong Huang
%A Nguyen Huy Hung
%A Bow-Shin Huang
%A Mei-Lin Yang
%A Ngo Xuan Luong
%A Tian-Shung Wu
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18044477
%X In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, ( 1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC 50 values in the range of 48.6 ¡À 1.2 and 99.8 ¡À 0.4 ¦ÌM.
%K Annona
%K triterpenoid
%K diterpenoid
%K NO inhibition
%K iNOS
%K macrophage
%U http://www.mdpi.com/1420-3049/18/4/4477