%0 Journal Article
%T Evaluation of anti-Schistosoma mansoni igG antibodies in patients with chronic schistosomiasis mansoni before and after specific treatment
%A VENDRAME C¨Ślia Maria V.
%A CARVALHO M¨˘rcia Dias T.
%A YAMAMOTO C¨Ślia Regina F.
%A NAKHLE Maria Cristina
%J Revista do Instituto de Medicina Tropical de SŁżo Paulo
%D 2001
%I Instituto de Medicina Tropical
%X The circumoval precipitin test (COPT), enzyme-linked immunosorbent assay (ELISA) and the immunoblotting anti-adult worm antigen (AWA) and soluble egg antigen (SEA) tests were applied to 17 chronically schistosome-infected patients for the detection of anti-Schistosoma mansoni antibodies before and on four occasions after oxamniquine administration over a period of six months. Compared to a control group, schistosomiasis patients showed high levels of IgG antibodies in AWA and SEA-ELISA. A decrease in IgG levels was observed six months after treatment, although negative reactions were not obtained. Significant decreases in IgG1, IgG3 and, mainly, IgG4, but not anti-SEA IgG2 levels were observed six months after treatment, again without negativity. Analysis of anti-AWA IgG antibodies by immunoblotting before treatment showed a 31 kDa strand in 14 patients (82%) which disappeared in three cases up to six months after treatment; furthermore, anti-SEA IgG antibodies showed the same band in nine patients (53%) before treatment, which disappeared in only four cases up to six months after treatment.
%K Schistosomiasis diagnosis
%K Schistosomiasis cure evaluation
%K Immunenzymatic tests
%K Immunoblotting
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000300007