%0 Journal Article
%T Neurohypophysial Receptor Gene Expression by Thymic T Cell Subsets and Thymic T Cell Lymphoma Cell Lines
%A I. Hansenne
%A G. Rasier
%A Ch. Charlet-renard
%A M.-P. Defresne
%A R. Greimers
%A C. Breton
%A J.-J. Legros
%A V. Geenen
%A H. Martens
%J Clinical and Developmental Immunology
%D 2004
%I Hindawi Publishing Corporation
%R 10.1080/10446670410001670481
%X Abstract Neurohypophysial oxytocin (OT) and vasopressin (VP) genes are transcribed in thymic epithelium, while immature T lymphocytes express functional neurohypophysial receptors. Neurohypophysial receptors belong to the G protein-linked seven-transmembrane receptor superfamily and are encoded by four distinct genes, OTR, V1R, V2R and V3R. The objective of this study was to identify the nature of neurohypophysial receptor in thymic T cell subsets purified by immunomagnetic selection, as well as in murine thymic lymphoma cell lines RL12-NP and BW5147. OTR is transcribed in all thymic T cell subsets and T cell lines, while V3R transcription is restricted to CD4
%U http://www.hindawi.com/journals/cdi/2004/150798/abs/