%0 Journal Article
%T Effect of Isolated Soy Protein on Prevention of Rheumatoid Arthritis in Collagen- Induced Rats
%A M. M. Shahi
%A S.A. Mahboob
%A F. Haidari
%A B. Rashidi
%J Qom University of Medical Sciences Journal
%D 2009
%I Qom University of Medical Sciences
%X Background and ObjectivesThe aim of this study was to investigate the effect of isolated soy protein on prevention of rheumatoid arthritis in collagen-induced rats. MethodsA total of 24 female Sprague-Dawley rats (body weights: 180-200g) were randomly divided into four equal groups including normal; control of rheumatoid arthritis; rheumatoid arthritis + isolated soy protein (7g/kg); rheumatoid arthritis + dexamethasone (1mg/kg). Experimentally rheumatoid arthritis in rats was induced by subcutaneous injection of collagen ¦©¦© emolsified in Incomplete Frund¡¯s Adjuvant in days 1 and 7. Treatments were gavaged to animals for 30 days, once a day. The severity of rheumatoid arthritis symptoms in paws were daily measured in double blind format by standard method. The statistical comparison between the experimental groups was performed by Independent -samples t- test and One-Way ANOVA using SPSS software. ResultsThe clinical symptoms of rheumatoid arthritis started from day 17.4¡À2.4, 20¡À4 and 14.1¡À1.9 in isolated soy protein, dexamethasone and control groups, respectively (P<0.05). The severity of clinical symptoms of rheumatoid arthritis on day 30 was 3.84¡À2.04, 2¡À1.78 and 6.5¡À1.76 in isolated soy protein, dexamethasone and control groups, respectively (P<0.05). At the end of the study, the incidence rates of rheumatoid arthritis in isolated soy protein and control groups was %83.33 and %100, respectively. ConclusionIsolated soy protein decreased the severity of clinical symptoms of rheumatoid arthritis. Therefore, it could be a key factor in prevention and even treatment of rheumatoid arthritis.Keywords: Soybean Proteins; Arthritis, Rheumatoid; Isoflavones.
%K Soybean Proteins
%K Arthritis
%K Rheumatoid
%K Isoflavones.
%U http://journal.muq.ac.ir/library/upload/article/88.9.1.pdf