%0 Journal Article
%T The impact of different GFR estimating equations on the prevalence of CKD and risk groups in a Southeast Asian cohort using the new KDIGO guidelines
%A Chagriya Kitiyakara
%A Sukit Yamwong
%A Prin Vathesatogkit
%A Anchalee Chittamma
%A Sayan Cheepudomwit
%A Somlak Vanavanan
%A Bunlue Hengprasith
%A Piyamitr Sritara
%J BMC Nephrology
%D 2012
%I BioMed Central
%R 10.1186/1471-2369-13-1
%X The prevalence of CKD and composite relative risk groups defined by eGFR from with Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI); standard (S) or Chinese(C) MDRD; Japanese CKD-EPI (J-EPI), Thai GFR (T-GFR) equations were compared in a Thai cohort (n = 5526)There was a 7 fold difference in CKD3-5 prevalence between J-EPI and the other Asian eGFR formulae. CKD3-5 prevalence with S-MDRD and CKD-EPI were 2 - 3 folds higher than T-GFR or C-MDRD. The concordance with CKD-EPI to diagnose CKD3-5 was over 90% for T-GFR or C-MDRD, but they only assigned the same CKD stage in 50% of the time. The choice of equation also caused large variations in each composite risk groups especially those with mildly increased risks. Different equations can lead to a reversal of male: female ratios. The variability of different equations is most apparent in older subjects. Stage G3aA1 increased with age and accounted for a large proportion of the differences in CKD3-5 between CKD-EPI, S-MDRD and C-MDRD.CKD prevalence, sex ratios, and KDIGO composite risk groupings varied widely depending on the equation used. More studies are needed to define the best equation for Asian populations.Chronic kidney disease (CKD) increases the risks of cardiovascular disease and ESRD progressively according to the severity of CKD [1]. In 2002, the Kidney Disease Outcomes Quality Initiative (KDOQI) organization published a guideline for diagnosis and classification of CKD into five stages according to severity using glomerular filtration rate (GFR) as the main criteria [2]. The presence of proteinuria was mandatory for stages 1 and 2 (GFR > 60 ml/min/1.73 m2). Patients with stage 3 (GFR 30 to < 60) or higher were regarded classified as CKD without requirement for the presence of proteinuria. Recent studies have shown that individuals with GFR 45 ml/min/1.73 m2 or less had increased risks compared to those with higher GFR [1,3-5]. The presence of proteinuria also increased cardio-renal events signifi
%K EGAT
%K glomerular filtration rate
%K renal failure
%K epidemiology
%K classification
%K kidney
%K Thai
%U http://www.biomedcentral.com/1471-2369/13/1