%0 Journal Article
%T Estimated glomerular filtration rate as an independent predictor of atherosclerotic vascular disease in older women
%A Joshua R Lewis
%A Wai Lim
%A Satvinder S Dhaliwal
%A Kun Zhu
%A Ee Mun Lim
%A Peter L Thompson
%A Richard L Prince
%J BMC Nephrology
%D 2012
%I BioMed Central
%R 10.1186/1471-2369-13-58
%X Complete 10-year verified mortality and hospitalization discharge records for atherosclerotic vascular disease was collected for a prospective study of 1,239 unselected female subject¡¯s£¿¡Ý£¿70 from the Calcium Intake Fracture Outcome Study (CAIFOS) with 10£¿years of follow-up. eGFR was compared to the current Framingham risk scores.The eGFR at baseline using the Modification of Diet in Renal Disease Study (MDRD) equation was 65.2£¿¡À£¿14.5£¿mL/min/1.73£¿m2 and 66.3£¿¡À£¿13.5£¿mL/min/1.73£¿m2 using the Chronic Kidney Disease EPIdemiology (CKD-EPI) equation. Over 10£¿years 30% of participants sustained an ASVD hospitalization or death. For every standard deviation (SD) reduction in eGFR using MDRD the odds ratio (OR) for ASVD hospitalization and deaths increased by 1.34 (1.18-1.53), P£¿<£¿0.001and 1.31 (1.14-1.50), P£¿<£¿0.001 in a model adjusted for Framingham 10-year general cardiovascular risk. Addition of eGFR by the MDRD equation to Framingham risk factors improved the net reclassification index by 5.9%, P£¿=£¿0.018 and the integrated discrimination improvement by 0.010£¿¡À£¿0.003, P£¿<£¿0.001 Similar results were seen using the CKD-EPI equation.Estimated glomerular filtration rate predicts ASVD outcomes independently of Framingham risk score predictions in elderly women and improves clinical prediction particularly of early ASVD.
%U http://www.biomedcentral.com/1471-2369/13/58/abstract