%0 Journal Article
%T Identification of peripheral inflammatory markers between normal control and Alzheimer's disease
%A Sam-Moon Kim
%A Juhee Song
%A Seungwoo Kim
%A Changsu Han
%A Moon Park
%A Youngho Koh
%A Sangmee Jo
%A Young-Youl Kim
%J BMC Neurology
%D 2011
%I BioMed Central
%R 10.1186/1471-2377-11-51
%X Plasma samples and clinical data were obtained from participants in the Ansan Geriatric Study (AGE study). Plasma concentrations of four candidate biomarkers were measured in the normal control (NC), MCI, and AD group: interleukin-8 (IL-8), IL-10, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-¦Á (TNF-¦Á).Body mass index (BMI), MMSE (Mini Mental State Examination), CDR(Clinical Dementia Rating) score and homocystein level were recorded with social and demographic information.Total of 59 subjects were randomly selected for this analysis [NC (n = 21), MCI(n = 20) and AD(n = 18)]. In demographic data, educational year was correlated with the diagnosis states (p < 0.0001). No significant differences in cardiovascular disease, BMI and use of NSAIDs were found in MCI or AD group compared with NC group, respectively. The involvement of inflammatory illness or conditions in subjects, WBC count, fibrinogen and homocystein of the three groups, but no significant differences were found in each groups. The plasma IL-8 level was lower in MCI and AD patients compared with the normal control group (respectively, p < 0.0001). The MCI and AD patients had similar MCP-1, IL-10, and TNF-¦Á level.Our study suggests the existence of an independent and negative relationship between plasma IL-8 levels and functional status in MCI and AD patients.Over the past decade, it has become clear that the brain maintains intricate relationships with the immune system. For example, proteins secreted from the brain can regulate physiological processes throughout the body [1]. In Alzheimer's disease (AD), the characteristic amyloid plaques and tangles in the brain are accompanied by prominent local stimulation of innate immune and inflammatory responses [2]. The possibility that inflammatory cytokines play a role in inflammation in the AD brain was initially suggested by the observation that the concentrations of these molecules are increased in AD tissue and are prominently associa
%K IL-8
%K biomarker
%K Alzheimer's
%U http://www.biomedcentral.com/1471-2377/11/51