%0 Journal Article
%T Nebivolol And Quinapril Reduce P-Wave Duration And Dispersion In Hypertensive Patients
%A Hasan Korkmaz
%A Orhan Onalan
%A Mehmet Akbulut
%A Y£¿lmaz Ozbay
%J Indian Pacing and Electrophysiology Journal
%D 2009
%I Indian Heart Rhythm Society
%X We aimed to investigate the effects of nebivolol and quinapril treatments on P-wave duration and dispersion in hypertensive patients. Hypertensive patients who were in sinus rhythm were assigned to the two treatment groups and received either 20 mg quinapril/day or 5 mg nebivolol/day. P-Wave dispersion (PWD) was measured at baseline and after four weeks of treatment and defined as the difference between the maximum (Pmax) and the minimum (Pmin) P-wave duration. The study group consisted of 54 patients (Mean age: 53 ¡À 9 years, 46% women) with 27 patients in each group. At 4-week follow up both treatment groups showed a significant reduction (p<0.001) in systolic (SBP) and diastolic blood pressure (DBP). Heart rate (HR) reduction was significant in patients receiving nebivolol (P=0.001). Both groups showed a similar (P=0.413 for PWD, p=0.651 for Pmax) but significant reduction in PWD (nebivolol: -16¡À14, P<0.0001 and quinapril: -13¡À11, P<0.0001) and Pmax (nebivolol: -10¡À11, P=0.001 and quinapril: -9¡À11, P=0.001). A 2 (Time) x 2 (Group) mixed-model repeated-measures analysis of variance revealed that the main effect of Time was significant for Pmax (P=0.002) and PWD (P=0.008) after controlling for changes in SBP, DBP and HR. However, the main effect of Group and Time x Group interaction was not significant for both variables (All p values >0.05). In conclusion, short-term treatment with nebivolol and quinapril produces a similar but significant reduction in Pmax and PWD in hypertensive patients. This effect is independent of blood pressure and heart rate changes.
%K P-wave duration
%K Nebivolol
%K Quinapril
%K Hypertension
%U http://www.ipej.org/0903/korkmaz.htm