%0 Journal Article
%T New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa
%A Ana Cristina Gomes-Santos
%A Thais Garcias Moreira
%A Archimedes Barbosa Castro-Junior
%A Bernardo Coelho Horta
%A Luisa Lemos
%A Deborah Nogueira Cruz
%A Mauro Andrade Freitas Guimar es
%A Denise Carmona Cara
%A Donna-Marie McCafferty
%A Ana Maria Caetano Faria
%J Clinical and Developmental Immunology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/560817
%X IL-10 is a regulatory cytokine that plays a major role in the homeostasis of the gut and this is illustrated by the fact that IL-10−/− mice develop spontaneous colitis. In this study, IL-10−/− mice were analyzed for immunological changes during colitis development. We found a reduced frequency of regulatory T cells CD4
%U http://www.hindawi.com/journals/cdi/2012/560817/