%0 Journal Article
%T Antigen-Specific T Cells and Cytokines Detection as Useful Tool for Understanding Immunity against Zoonotic Infections
%A Annalisa Agnone
%A Alessandra Torina
%A Gesualdo Vesco
%A Sara Villari
%A Fabrizio Vitale
%A Santo Caracappa
%A Marco Pio La Manna
%A Francesco Dieli
%A Guido Sireci
%J Clinical and Developmental Immunology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/768789
%X Zoonoses include a broad range of diseases, that are becoming of great interest, due to the climate changing, that cause the adaptation of vectors to new niches and environments. Host immune responses play a crucial role in determining the outcome of infections, as documented by expansion of antigen-specific T cells during several zoonotic infections. Thus, understanding of the contribution of antigen-specific T-cell subsets in the host immune response is a powerful tool to evaluate the different immunological mechanisms involved in zoonotic infections and for the development of effective vaccines. In this paper we discuss the role of T cells in some eukaryotic and prokaryotic infectious models.
%U http://www.hindawi.com/journals/cdi/2012/768789/