%0 Journal Article
%T PHARMACEUTICAL PRODUCTS IN THE ENVIRONMENT: SOURCES, EFFECTS AND RISKS PRODUCTOS FARMAC谷UTICOS EN EL AMBIENTE: FUENTES, EFECTOS Y RIESGOS
%A Jhon F. NARVAEZ V.
%A Claudio JIMENEZ C.
%J Vitae
%D 2012
%I Universidad de Antioquia
%X Pharmaceuticals and personal care products have become an environmental problem in recent years. Their physicochemical properties and persistence in the environment have allowed the distribution of degradates and parent compounds in water, soil, air and food. The widespread use of pharmaceuticals and personal care products in hospitals, domestic residences, agricultural and industrial facilities has increased their discharge into the water bodies, and its toxicity has started to manifest in different biological components of ecosystems. The development of methods for sample treatment and instrumental analysis techniques has enabled the separation, identification and quantification of active ingredients and degradates with higher environmental impact, at concentrations of parts per billion or even parts per trillion. In addition, in vitro and in vivo assays have demonstrated their ecotoxicity in water, driving them to the classification of emerging organic pollutants, whose waste is indeterminate. Although their adverse effects are still unknown, they could have strong implications for global public health. This review presents the dynamics and the development of research over the past ten years about the presence of non-steroidal anti-inflammatory analgesics, antihypertensives, antibiotics and other drugs in water bodies. Similarly, it described the impact of pharmaceutical activity, hospital services and domestic effluents on water quality. Los productos farmac谷uticos y los productos para el cuidado personal han representado un problema ambiental en los 迆ltimos a os. Sus propiedades fisicoqu赤micas y su persistencia en el ambiente han permitido la distribuci車n de muchos metabolitos parentales en el agua, en el suelo, en el aire y en los alimentos. Su amplio uso hospitalario, dom谷stico, agr赤cola e industrial ha aumentado las descargas en los cuerpos de agua y su impacto ambiental y toxicidad han empezado a manifestarse en los diferentes componentes biol車gicos de los ecosistemas. El desarrollo de metodolog赤as de tratamiento de muestra y las t谷cnicas instrumentales de an芍lisis han permitido la separaci車n, identificaci車n y cuantificaci車n a concentraciones de partes por bill車n e incluso de partes por trill車n de principios activos y productos de degradaci車n de gran impacto ambiental. Adicionalmente, los ensayos in vitro e in vivo han demostrado su ecotoxicidad acu芍tica, permitiendo clasificar estas sustancias como contaminantes org芍nicos emergentes, cuyos vertimientos son indeterminados y su impacto sobre los ecosistemas es silencioso pero de grandes repercus
%K productos farmac谷uticos y para el cuidado personal
%K ecotoxicidad
%K contaminantes org芍nicos emergentes
%K antibi車ticos
%K analg谷sicos
%K Toxicity tests
%K environmental pollutants
%K organic pollutants
%K analgesics
%K pharmaceuticals and personal care products
%U http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042012000100010