%0 Journal Article
%T Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice
%A Vijayalakshmi A
%A Ravichandiran V
%A Anbu J
%A Velraj Malarkodi
%J Indian Journal of Pharmacology
%D 2011
%I Medknow Publications
%X Objective : To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice. Materials and Methods : The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test. Results : The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups. Conclusion : The EESC and EAF may help to control petit mal and grand mal seizures.
%K Epilepsy
%K China root
%K Smilax china
%K neurotoxicity
%U http://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=1;spage=27;epage=30;aulast=Vijayalakshmi