%0 Journal Article
%T Nephroprotective effect of Bauhinia variegata (linn.) whole stem extract against cisplatin-induced nephropathy in rats
%A Pani Saumya
%A Mishra Satyaranjan
%A Sahoo Sabuj
%A Panda Prasana
%J Indian Journal of Pharmacology
%D 2011
%I Medknow Publications
%X The nephroprotective activity of the ethanolic extract of Bauhinia variegata (Linn.) whole stem against cisplatin-induced nephropathy was investigated by an in vivo method in rats. Acute nephrotoxicity was induced by i.p. injection of cisplatin (7 mg/kg of body weight (b.w.)). Administration of ethanol extract at dose levels of 400 and 200 mg/kg (b.w.) to cisplatin-intoxicated rats for 14 days attenuated the biochemical and histological signs of nephrotoxicity of cisplatin in a dose-dependent fashion. Ethanol extract at 400 mg/kg decreased the serum level of creatinine (0.65 ¡À 0.09; P<0.001) and urea (32.86 ¡À 5.88; P<0.001) associated with a significant increase in body weight (7.16 ¡À 1.10; P<0.001) and urine volume output (11.95 ¡À 0.79; P<0.05) as compared to the toxic control group. The ethanol extract of B. variegata at 400 mg/kg (b.w.) exhibited significant and comparable nephroprotective potential to that of the standard polyherbal drug cystone. The statistically (one-way-ANOVA followed by Tukey-Kramer multiple comparison) processed results suggested the protective action of B. variegate whole stem against cisplatin-induced nephropathy.
%K Cisplatin
%K nephrotoxicity
%K Kanchana
%U http://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=2;spage=200;epage=202;aulast=Pani