%0 Journal Article
%T Study of the complexation behaviour of fexofenadine with ¦Â-cyclodextrin
%A Sapkal Nidhi
%A Kilor Vaishali
%A Shewale Bharti
%A Bhusari K
%J Indian Journal of Pharmaceutical Sciences
%D 2010
%I Medknow Publications
%X Fexofenadine is a selective histamine H 1 receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and ¦Â-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with ¦Â-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with ¦Â-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with ¦Â-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results.
%K ¦Â-cyclodextrin
%K kneading
%K co-precipitation
%K fexofenadine
%K inclusion complexes
%U http://www.ijpsonline.com/article.asp?issn=0250-474X;year=2010;volume=72;issue=3;spage=318;epage=323;aulast=Sapkal