%0 Journal Article
%T Acyclovir and hydrocortisone cream for the early treatment of recurrent cold sores
%A Carrie A Sailer
%A Spotswood L Spruance
%A Christopher M Hull
%J Virus Adaptation and Treatment
%D 2011
%I Dove Medical Press
%X Carrie A Sailer1, Spotswood L Spruance2, Christopher M Hull11Department of Dermatology, 2Department of Medicine, Division of Infectious Diseases, University of Utah, Salt Lake City, USAAbstract: Current antiviral therapies for herpes simplex labialis primarily reduce healing time. Since the host immune response also plays a role in both controlling recurrent infection as well as producing clinical symptoms, new studies are showing efficacy using topical corticosteroids. This review will evaluate the safety and efficacy of 5% acyclovir¨C1% hydrocortisone cream (Xerese [US], Xerclear [Europe]) for treatment of patients with herpes simplex labialis. A large, randomized, double-blind, placebo-controlled study recently demonstrated that treatment with 5% acyclovir¨C1% hydrocortisone cream significantly decreased the percentage of ulcerative lesions, reduced lesion healing time, and decreased mean lesion area compared with both topical acyclovir alone and vehicle.Keywords: herpes labialis, herpes simplex virus, HSV, acyclovir, hydrocortisone, ME-609, Xerese, Xerclear
%U http://www.dovepress.com/acyclovir-and-hydrocortisone-cream-for-the-early-treatment-of-recurren-a6045