%0 Journal Article
%T Protective effect of ethanol extract of Gymnosporia montana (Roth) Bemth. in paracetamol-induced hepatotoxicity in rats
%A Patel Parvati
%A Patel T
%A Shah P
%A Baxi Seema
%J Indian Journal of Pharmaceutical Sciences
%D 2010
%I Medknow Publications
%X The aim of the present study was to explore the hepatoprotective activity of the ethanol extract of leaves of Gymnosporia montana (Roth) Bemth. (Family: Celastraceous) against paracetamol-induced hepatotoxicity. Hepatotoxicity in Wistar rats was induced by a single intraperitoneal dose of 500 mg/kg of paracetamol and studied by comparing parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and histopathological examination of liver. Pre and post-treatment with ethanol extract of Gymnosporia montana (Roth) Bemth. at doses of 50 and 100 mg/kg was studied by comparing the above mentioned parameters with silymarin (100 mg/kg) as standard. Both doses of ethanol extract of Gymnosporia montana (Roth) Bemth. were found to be hepatoprotective. Extract at the dose of 100 mg/kg produced effects comparable to those of silymarin. The present study indicates that alcohol extract of Gymnosporia montana (Roth) Bemth. possessed significant hepatoprotective activity.
%K Ethanol extract
%K Gymnosporia montana (Roth) Bemth.
%K hepatoprotective activity
%K paracetamol
%U http://www.ijpsonline.com/article.asp?issn=0250-474X;year=2010;volume=72;issue=3;spage=392;epage=396;aulast=Patel