%0 Journal Article
%T PROTECTIVE EFFECT OF Solanum Pubescens LINN ON CCL4 INDUCED HEPATOTOXICITY IN ALBINO RATS
%A M.Pushpalatha
%A T.Ananthi
%J Mintage Journal of Pharmaceutical and Medical Sciences
%D 2012
%I Mintage Journals
%X Ethanol extract of Solanum pubescens Linn was evaluated for hepato protective and antioxidant activities in rats. The plant extract (500mg/kg/day) showed a remarkable hepatoprotective and antioxidant activity against Carbon tetrachloride (CCl4)-induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. CCl4 induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, LPO with a reduction of total protein, superoxide dismutase (SOD), catalase, and reduced glutathione (GSH). Treatment of rats with plant extract (500 mg/kg) significantly (P<0.01) altered serum marker enzymes and antioxidant levels to near normal against CCl4 - treated rats. The activity of the extract at dose of 500 mg/kg was comparable to the standard drug, Silymarin (50 mg/kg, p.o.). Histopathological examination of the liver tissues supported the hepatoprotective activity of plant.
%K Solanum pubescens Linn
%K CCl4
%K Hepatoprotective
%K Silymarin
%U http://www.mintagejournals.com/index_htm_files/101.pdf