%0 Journal Article
%T Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences
%A Daichi Hayashi
%A Ali Guermazi
%A C Kent Kwoh
%A Michael J Hannon
%A Carolyn Moore
%A John M Jakicic
%A Stephanie M Green
%A Frank W Roemer
%J BMC Musculoskeletal Disorders
%D 2011
%I BioMed Central
%R 10.1186/1471-2474-12-198
%X Included were 201 subjects aged 35-65 with frequent knee pain. 3T MRI was performed with the same sequence protocol as in the Osteoarthritis Initiative (OAI). In a primary reading subchondral bone marrow edema-like lesions were assessed according to the WORMS system. Two hundred subregions with such lesions were randomly chosen. The extent of subchondral bone marrow edema-like lesions was re-evaluated separately using sagittal IW fs and DESS sequences according to WORMS. Lesion size and confidence of the differentiation between subchondral bone marrow edema-like lesions and subchondral cysts located within or adjacent to them was rated from 0 to 3. Wilcoxon signed-rank tests and chi-square statistics were used to examine differences between the two sequences.Of 200 subchondral bone marrow edema-like lesions detected by IW fs sequence, 93 lesions (46.5%) were not depicted by the DESS sequence. The IW fs sequence depicted subchondral bone marrow edema-like lesions to a larger extent than DESS (p < 0.0001), and the opposite was true for subchondral cysts. Confidence scores for differentiation of the two types of lesions were not significantly different between the two sequences.In direct comparison the IW fs sequence depicts more subchondral bone marrow edema-like lesions and better demonstrate the extent of their maximum size. The DESS sequence helps in the differentiation of subchondral bone marrow edema-like lesions and subchondral cysts. The IW fs sequence should be used for determination of lesion extent whenever the size of subchondral bone marrow edema-like lesions is the focus of attention.Subchondral bone marrow edema-like lesions (BML) are defined as non-cystic areas of ill-delineated hyperintensity on fluid-sensitive fast spin echo (FSE) fat suppressed (fs) pulse sequences and of hypointensity on T1-weighted (T1W) spin echo (SE) images [1]. They are one of the features of osteoarthritis (OA) detected on MRI and are observed regularly in conjunction with stru
%K bone marrow lesion
%K cyst
%K MRI
%K knee
%K osteoarthritis
%U http://www.biomedcentral.com/1471-2474/12/198