%0 Journal Article
%T Small choroidal melanoma with monosomy 3
%A Ghassemi Fariba
%A Shields Carol
%A Materin Miguel
%A Shields Jerry
%J Middle East African Journal of Ophthalmology
%D 2010
%I Medknow Publications
%X Purpose: To report a patient with small juxtapapillary choroidal melanoma with chromosome 3 monosomy treated with I 125 plaque and transpupillary thermotherapy (TTT). A 64-year-old Caucasian male presented with painless blurred vision of the left eye. Ocular examination disclosed a small juxtapapillary choroidal melanocytic tumor with overlying subretinal fluid and orange pigment. Ultrasound showed an elevated choroidal mass of 2 mm thickness with low reflectivity on A-scan and hollowness on B scan, consistent with a small choroidal melanoma. The patient was treated with plaque I 125 radiotherapy combined with one session of TTT. Genetic testing of the tumor cells obtained by fine needle aspiration biopsy showed chromosome 3 monosomy. At 1 year after treatment, the tumor was regressed with resolution of subretinal fluid and 20/40 visual acuity. A small choroidal melanoma can manifest monosomy of chromosome 3, a known predictive factor for the development of systemic metastasis.
%K Choroidal Melanoma
%K Chromosome 3
%K Eye
%K Metastases
%K Monosomy
%K Small Choroidal Melanoma
%U http://www.meajo.org/article.asp?issn=0974-9233;year=2010;volume=17;issue=3;spage=268;epage=269;aulast=Ghassemi