%0 Journal Article
%T Peptides¡¯ role in autism with emphasis on exorphins
%A Karl L. Reichelt
%A Dag Tveiten
%A Anne-Mari Knivsberg
%A Gunnar Br£¿nstad
%J Microbial Ecology in Health and Disease
%D 2012
%I Co-Action Publishing
%R 10.3402/mehd.v23i0.18958
%X Problem: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. Methods: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid¨Cacetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. Results: We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. Conclusion: Exorphins are found in urine of autistic children and may account for their symptoms.
%K autism
%K peptides
%K exorphins
%K mass-spectroscopy
%U http://www.microbecolhealthdis.net/index.php/mehd/article/view/18958/23930