%0 Journal Article
%T The Current Practice of Screening, Prevention, and Treatment of Androgen-Deprivation-Therapy Induced Osteoporosis in Patients with Prostate Cancer
%A Humaid O. Al-Shamsi
%A Arthur N. Lau
%A Kartika Malik
%A Abdulaziz Alamri
%A George Ioannidis
%A Tom Corbett
%A J. D. Adachi
%A Alexandra Papaioannou
%J Journal of Oncology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/958596
%X Introduction. ADT is used in the management of locally advanced and metastatic disease. The detrimental effect of ADT on bone density is well documented. This study assesses care gaps in screening, prevention and treatment of osteoporosis among prostate cancer patients. Methods. We conducted a retrospective cohort study for patients diagnosed with non-metastatic prostate cancer on ADT. Charts from a tertiary oncology center were assessed for utilization of DXA scan, prescription of calcium, vitamin D, calcitonin and bisphosphonates.Bivariate analysis was used to determine the effect of patient characteristics and likelihood for osteoporosis screening. Results. 149 charts were reviewed, with 3-year mean follow-up. 58.8% of men received a baseline DXA, of which 20.3% had a repeat DXA within their follow-up periods.In all, 28% were appropriately screened and managed for osteoporosis (received repeat DXA, bisphosphonate). In bivariate analysis, the number of ADT injections which correlate with the duration of androgen suppression was significantly associated with the number of DXA scans. Conclusions. Our study found a care gap in the screening, prevention, and treatment of osteoporosis in this population. Patients receiving the most ADT injections were more likely to be screened. Our results suggest healthcare providers treating prostate cancer are insufficiently screening and treating this susceptible population. We suggest baseline measurement of BMD at the initiation of ADT with periodic reassessment during therapy. 1. Introduction Prostate cancer is the most frequently diagnosed cancer and is the most common cancer to afflict Canadian men; around 25,500 men will be diagnosed with prostate cancer in 2011 in Canada alone [1], and aside from nonmelanoma skin cancer it is the most common cancer diagnosed in American men [1]. Rates of prostate cancer in men are comparable to rates of breast cancer in women and since 1995, the incidence of prostate cancer in both the United States and Canada have increased by 1 percent annually [1]. This is largely due to the aging of the population [1]. Androgen deprivation therapy (ADT) comprises of gonadotropin-releasing hormone agonists and is usually administered in a depot form. ADT remains the standard first-line therapy for metastatic prostate cancer. In addition to metastatic disease, ADT has also been shown to improve survival in patients with locally advanced or high-risk localized prostate cancer [2¨C4]. There is an increasing role for ADT in patients with localized prostate cancer and low-volume extracapsular
%U http://www.hindawi.com/journals/jo/2012/958596/