%0 Journal Article
%T Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines
%A Umme Ruman Siddiqi
%A Prisca Susan A. Leano
%A Haorile Chagan-Yasutan
%A Beata Shiratori
%A Hiroki Saitoh
%A Yugo Ashino
%A Yasuhiko Suzuki
%A Toshio Hattori
%A Elizabeth Freda O. Telan
%J Clinical and Developmental Immunology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/610707
%X Anti-tubercular-glycolipid-IgG (TBGL-IgG) and -IgA (TBGL-IgA) antibodies, and the QuantiFERON-TB Gold test (QFT) were compared in healthcare workers (HCWs, =31) and asymptomatic human immunodeficiency virus-carriers (HIV-AC, =56) in Manila. In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG, and -IgA, respectively. The TBGL-IgG positivity was significantly higher (=0.02) in QFT-positive than QFT-negative HCWs. Both TBGL-IgG- and -IgA-positive cases were only found in QFT-positive HCWs (27%). The plasma IFN-γ levels positively correlated with TBGL-IgA titers (=0.74, =0.005), but not TBGL-IgG titers in this group, indicating that mucosal immunity is involved in LTBI in immunocompetent individuals. The QFT positivity in HIV-AC was 31% in those with CD4
%U http://www.hindawi.com/journals/cdi/2012/610707/