%0 Journal Article
%T Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study
%A Anja Vogt
%A Ursula Kassner
%A Ulrike Hostalek
%A Elisabeth Steinhagen-Thiessen
%J Vascular Health and Risk Management
%D 2007
%I Dove Medical Press
%X Anja Vogt1, Ursula Kassner1, Ulrike Hostalek2, Elisabeth Steinhagen-Thiessen11Charite-Universitatsmedizin Berlin, Germany; 2Merck KGaA, Darmstadt, GermanyAbstract: Low HDL-cholesterol (<1.02 mmol/L [40 mg/dL] in men or <1.29 mmol/L [50 mg/dL] in women) occurs in about one-third of European patients with dyslipidemia and is an independent cardiovascular risk factor. Simultaneous correction of low HDL-cholesterol and high totalcholesterol and LDL-cholesterol may provide reductions in cardiovascular morbidity and mortality beyond those possible with statins alone. Nicotinic acid (niacin in the US) is the most effective means of increasing HDL-cholesterol available and has been shown to reduce cardiovascular event rates significantly. Niaspan  (prolonged-release nicotinic acid) provides a convenient, once-daily means of administering nicotinic acid. Clinical studies with Niaspan  have demonstrated marked, long-term increases in HDL-cholesterol with additional useful benefits on triglycerides, LDLcholesterol, and lipid sub-profiles. The NAUTILUS study demonstrated the beneficial efficacy and tolerability profiles of Niaspan  in a usual-care setting. The most common side-effect of Niaspan  is flushing, which infrequently causes treatment discontinuation and which usually subsides over continued treatment. The ARBITER 2 and ARBITER 3 studies showed 1¨C2 years of treatment with Niaspan  plus a statin induced regression of atherosclerosis in patients with coronary artery disease. The effect of Niaspan -statin treatment, relative to a statin alone, on clinical cardiovascular outcomes is currently under evaluation. Niaspan  represents a practical means of correcting low HDL-cholesterol, an independent risk factor for adverse cardiovascular outcomes.Keywords: prolonged-release nicotinic acid, Niaspan , niacin, dyslipidemia, HDL-cholesterol cardiovascular risk
%U http://www.dovepress.com/prolonged-release-nicotinic-acid-for-the-management-of-dyslipidemia-an-a1496