%0 Journal Article
%T Effects of early treatment with zofenopril in patients with myocardial infarction and metabolic syndrome: the SMILE Study
%A Claudio Borghi
%A Arrigo FG Cicero
%A Ettore Ambrosioni
%J Vascular Health and Risk Management
%D 2008
%I Dove Medical Press
%X Claudio Borghi, Arrigo FG Cicero, Ettore AmbrosioniDepartment of Clinical Medicine, University of Bologna, Bologna, Italy. On behalf of the Survival of Myocardial Infarction Long-term Evaluation (SMILE) StudyObjective: To evaluate the clinical efficacy of the early administration of zofenopril in a group of patients with and without metabolic syndrome (MS+ and MS每) and anterior myocardial infarction enrolled in the Survival of Myocardial Infarction Long-Term Evaluation (SMILE) Study.Methods: Patients were randomized double-blind to zofenopril (n = 719) or placebo (n = 699) for 6 weeks. The primary end point was the effect of treatment on the 6-week combined occurrence of death and severe congestive heart failure. The secondary end point was the 1-year mortality rate.Results: Of the 1418 patients included in this post-hoc analysis, 686 (48.3%) had MS. After 6 weeks of treatment zofenopril significantly reduced the incidence of all-cause death and severe congestive failure (risk reduction: 69%, 95% CI: 7每78; 2p = 0.002) in MS+ patients. This was the case for 1-year mortality, too (29%, 95% CI: 4每41; 2p = 0.048). Zofenopril was effective also in MS  patients but the amount of relative risk reduction was less than in MS+ for both the primary (每11%; 2p = 0.61) and secondary endpoint (每19%; 2p = 0.025).Conclusions: Results of this post-hoc analysis of the SMILE Study demonstrate the striking benefit of early administration of zofenopril in MS+ patients with acute anterior myocardial infarction.Keywords: SMILE Study, angiotensin converting enzyme inhibitor, zofenopril, myocardial infarction, metabolic syndrome
%U http://www.dovepress.com/effects-of-early-treatment-with-zofenopril-in-patients-with-myocardial-a1911