%0 Journal Article
%T Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
%A Chakraborty Nitya
%J Indian Journal of Human Genetics
%D 2009
%I Medknow Publications
%X Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important.
%K Tumor antigens
%K Cytotoxic T Lymphocyte (CTL) Regulatory T cells (Tregs)
%K Interleukin-10 (IL-10)
%U http://www.ijhg.com/article.asp?issn=0971-6866;year=2009;volume=15;issue=1;spage=3;epage=8;aulast=Chakraborty