%0 Journal Article
%T Agreement of left ventricular mass in steady state free precession and delayed enhancement MR images: implications for quantification of fibrosis in congenital and ischemic heart disease
%A Sigurdur S Stephensen
%A Marcus Carlsson
%A Martin Ugander
%A Henrik Engblom
%A Goran Olivecrona
%A David Erlinge
%A Hakan Arheden
%J BMC Medical Imaging
%D 2010
%I BioMed Central
%R 10.1186/1471-2342-10-4
%X Ethics committees approved human and animal studies. Informed written consent was obtained from all patients. SSFP and DE images were acquired in 60 patients (20 with infarction, 20 without infarction and 20 pediatric patients). Ex vivo MRI was used as reference method for LVM in 19 pigs and compared to in vivo SSFP and DE.LVM was greater in SSFP than in DE (p < 0.001) with a bias of 5.0 ¡À 6.7% in humans (r2 = 0.98), and a bias of 7.3 ¡À 6.7% (p < 0.001) in pigs (r2 = 0.83). Bias for SSFP and DE images compared to ex vivo LVM was -0.2 ¡À 9.0% and -7.7 ¡À 8.5% respectively.LVM was higher when measured with SSFP compared to DE. Thus, the percentage infarction of the LV will differ if SSFP or DE is used to determine LVM. There was no significant difference between SSFP and ex vivo LVM suggesting that SSFP is more accurate for LVM quantification. To avoid intrinsic error due to the differences between the sequences, we suggest using DE when expressing infarct as a percentage of LVM.Myocardial infarct size influences patient prognosis [1] and left ventricular (LV) remodeling [2]. Therefore, quantification of infarct size as a percentage of the LV myocardium is of great interest in preclinical and clinical trials as well as in the clinical setting [3,4]. Magnetic resonance imaging (MRI) has been established as the in vivo reference method for quantification of left ventricular mass (LVM) and myocardial infarction [5-10]. Myocardial infarction is quantified in delayed enhancement (DE) MRI where infarcted myocardium is hyperenhanced [11]. Furthermore, DE-MRI has recently been shown to have the capability to detect fibrosis of the right ventricle in patients with surgically corrected congenital heart disease [12-14]. The percentage infarcted or fibrotic myocardium of the LV is most often calculated as the hyperenhanced myocardium in the DE images divided by LVM in the steady state free precession (SSFP) cine images [15-17]. However, investigators have also calculated the percen
%U http://www.biomedcentral.com/1471-2342/10/4