%0 Journal Article
%T Tracking type specific prevalence of human Papillomavirus in cervical pre-cancer: a novel sampling strategy
%A Edward K Waters
%A John Kaldor
%A Andrew J Hamilton
%A Anthony MA Smith
%A David J Philp
%A Basil Donovan
%A David G Regan
%J BMC Medical Research Methodology
%D 2012
%I BioMed Central
%R 10.1186/1471-2288-12-77
%X A truncated sequential sampling plan that collects a variable sample size was designed to detect changes in the type-specific distribution of HPV in CIN-3. Computer simulation to evaluate the accuracy of the plan at classifying the prevalence of an HPV type as low (< 5%), moderate (5-15%), or high (> 15%) and the average sample size collected was conducted and used to assess its appropriateness as a surveillance tool.The plan classified the proportion of CIN-3 lesions positive for an HPV type very accurately, with >90% of simulations correctly classifying a simulated data-set with known prevalence. Misclassifying an HPV type of high prevalence as being of low prevalence, arguably the most serious kind of potential error, occurred£¿<£¿0.05 times per 100 simulations. A much lower sample size (21¨C22 versus 40¨C48) was required to classify samples of high rather than low or moderate prevalence.Truncated sequential sampling enables the proportion of CIN-3 due to an HPV type to be accurately classified using small sample sizes. Truncated sequential sampling should be used for type-specific HPV surveillance in the vaccination era.
%U http://www.biomedcentral.com/1471-2288/12/77/abstract