%0 Journal Article
%T Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection
%A Martyn A. French
%A Laila N. Abudulai
%A Sonia Fernandez
%J Vaccines
%D 2013
%I MDPI AG
%R 10.3390/vaccines1030328
%X The development of vaccines to treat and prevent human immunodeficiency virus (HIV) infection has been hampered by an incomplete understanding of ˇ°protectiveˇ± immune responses against HIV. Natural control of HIV-1 infection is associated with T-cell responses against HIV-1 Gag proteins, particularly CD8 + T-cell responses restricted by ˇ°protectiveˇ± HLA-B alleles, but other immune responses also contribute to immune control. These immune responses appear to include IgG antibodies to HIV-1 Gag proteins, interferon-a-dependant natural killer (NK) cell responses and plasmacytoid dendritic cell (pDC) responses. Here, it is proposed that isotype diversification of IgG antibodies against HIV-1 Gag proteins, to include IgG2, as well as IgG3 and IgG1 antibodies, will broaden the function of the antibody response and facilitate accessory cell responses against HIV-1 by NK cells and pDCs. We suggest that this should be investigated as a vaccination strategy for HIV-1 infection.
%K HIV
%K vaccine
%K HIV-1 Gag
%K IgG antibody diversification
%K IgG subclasses
%U http://www.mdpi.com/2076-393X/1/3/328