%0 Journal Article
%T Polimorfizm pojedynczych nukleotyd¨®w w genach naprawy DNA przez rekombinacj  homologiczn  (XRCC2 i RAD51) a ryzyko sporadycznego raka piersi w Polsce
%A Hanna Romanowicz
%A Beata Smolarz
%A Jakub Baszczy¨½ski
%A Marek Zadro£¿ny
%J Przegl£¿d Menopauzalny
%D 2011
%I Termedia Publishing House
%X Background: Single nucleotide polymorphisms in the DNA repair genes have been extensively studied inassociation with various human cancers such as breast cancer. Material and methods: We investigated an association of polymorphisms in the DNA repair genesXRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assaysin 80 patients with breast cancer and 80 controls. Results: The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differsignificantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91¨C5.72), p = 0.04). Conclusion: G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadicbreast cancer in Polish women.
%K XRCC2
%K RAD51
%K breast cancer
%K gene polymorphism
%U http://www.termedia.pl/Polimorfizm-pojedynczych-nukleotydow-w-genach-naprawy-DNA-r-nprzez-rekombinacje-homologiczna-XRCC2-i-RAD51-a-ryzyko-sporadycznego-raka-piersi-w-Polsce,4,16339,1,0.html