%0 Journal Article
%T Evaluating Percutaneous Nephrolithotomy-Induced Kidney Damage by Measuring Urinary Concentrations of ¦Â-2 Microglobulin
%A Farzaneh Sharifiaghdas
%A Amir Hossein Kashi
%A Ramin Eshratkhah
%J Urology Journal
%D 2011
%I Shaheed Beheshti University of Medical Sciences
%X PURPOSE: To assess percutaneous nephrolithotomy (PCNL)-induced kidney tubular damage and the associated factors.MATERIALS AND METHODS: One hundred and eight patients who have undergone PCNL from May 2007 to October 2007 were recruited in this study. Urinary level of ¦Â2-microglobulin (U¦Â2MG) was measured on the day before the operation as well as on the 1st, and 7thpost PCNL days. Percutaneous nephrolithotomy was performed using standard method. Patients¡¯ demographic and peri-operative data were collected to evaluate factors influencing renal injury.RESULTS: Median urinary levels of ¦Â2-microglobulin on pre-operative, 1st, and 7thpostoperative days were 0.2 mg/dL (range, 0.1 to 82), 0.4 mg/dL (range, 0.2 to 97), and 0.2 mg/dL (range, 0.2 to 114), respectively. High levels of U¦Â2MG (> 2.3 mg/dL) were observed in 10 (9%), 20 (19%), and 10 (9%) patients pre-operatively and on the 1st, and 7thpostoperative days, respectively. In multivariable analysis, U¦Â2MG on the 1stpostoperative day was associated with pre-operative serum creatinine level (P < .001) and diabetes mellitus (P = .05), while U¦Â2MG on the 7thday after the operation was associated with pre-operative serum creatinine level (P = .01), diabetes mellitus (P = .01), and PCNL time (P = .02).CONCLUSION: Percutaneous nephrolithotomy does not cause kidney tubular injury beyond one week. In patients with pre-operative high serum creatinine concentration, diabetes mellitus, and/or long operation time, the likelihood of the kidney damage is higher than others.
%K percutaneous nephrolithotomy
%K beta 2-microglobulin
%K acute kidney injury
%U www.urologyjournal.org/index.php/uj/article/view/1234/600