%0 Journal Article
%T Tuberculosis after gastrectomy, plasmatic concentration of antitubercular drugs
%A Giuseppe Vittorio De Socio
%A Antonio D'Avolio
%A Alessio Sgrelli
%A Lorena Baietto
%J Mediterranean Journal of Hematology and Infectious Diseases
%D 2012
%I 
%R 10.4084/mjhid.2012.
%X We report pharmacokinetic data on two gastrectomized, patients affected by tuberculosis. Drugs plasmatic concentrations were measured after seven days of oral therapy by a validated high performance liquid chromatography-mass spectrometry (HPLC-MS) method and the area under the concentration-time-curve (AUC) over 24 hours (AUC0-24) was calculated. A sub-therapeutic level of isoniazid was found in a patient with total gastrectomy with a Cmax of 0,395 mgL and AUC0-24 level of 4.75 hr*mg/L. The level of the other antitubercular drugs was adequate. Measurement of drug level in gastrectomy patients with tuberculosis is warranted.
%K tuberculosis
%K gastrectomy
%K high performance liquid chromatography
%K therapeutic drug monitoring.
%U http://www.mjhid.org/article/view/9336