%0 Journal Article
%T Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy
%A Wiwanitkit Viroj
%J Indian Journal of Dermatology, Venereology and Leprology
%D 2008
%I Medknow Publications
%X Background and Aims: Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified. Methods: In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool. Results: According to this study, nine strong possible ligands can be identified. Conclusion: These sites can be useful for further drug-development studies.
%K ErbB2
%K Leprosy
%K Ligand binding
%K Trastuzumab
%U http://www.ijdvl.com/article.asp?issn=0378-6323;year=2008;volume=74;issue=1;spage=32;epage=34;aulast=Wiwanitkit