%0 Journal Article
%T Stevens Johnson syndrome, toxic epidermal necrolysis and SJS-TEN overlap: A retrospective study of causative drugs and clinical outcome
%A Sharma Vinod
%A Sethuraman Gomathy
%A Minz Anil
%J Indian Journal of Dermatology, Venereology and Leprology
%D 2008
%I Medknow Publications
%X Background and Aims: Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap are serious adverse cutaneous drug reactions. Drugs are often implicated in these reactions. Methods: A retrospective analysis of inpatients¡ä data with these dermatological diagnoses were carried out for three years, to study the causative drugs, clinical outcome, and mortality in these conditions. Results: Thirty patients (15 TEN, nine SJS-TEN overlap, and six SJS) were admitted. In 21 cases, multiple drugs were implicated whereas single drugs were responsible in nine. Anticonvulsants (35.08%) were the most commonly implicated drugs followed by antibiotics (33.33%) and NSAIDS (24.56%). Twenty-five patients recovered whereas five died (four TEN, one SJS-TEN overlap). Conclusion: Anticonvulsants, antibiotics and NSAIDs were the most frequently implicated drugs. TEN causes higher mortality than both SJS and SJS-TEN overlap.
%K Anticonvulsants
%K SJS-TEN overlap
%K Stevens Johnson syndrome
%K toxic epidermal necrolysis
%U http://www.ijdvl.com/article.asp?issn=0378-6323;year=2008;volume=74;issue=3;spage=238;epage=240;aulast=Sharma