%0 Journal Article
%T No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families
%A Gao Gao
%A Zhen-Lin Zhang
%A Jin-Wei He
%A Hao Zhang
%A Hua Yue
%A Wei-Wei Hu
%A Jie-Mei Gu
%A Wen-Zhen Fu
%A Yun-Qiu Hu
%A Miao Li
%A Yu-Juan Liu
%A Jin-Bo Yu
%J BMC Medical Genetics
%D 2010
%I BioMed Central
%R 10.1186/1471-2350-11-1
%X We recruited 1,260 subjects from 401 female-offspring nuclear families and 1,296 subjects from 427 male-offspring nuclear families and genotyped four tagging single nucleotide polymorphisms (tagSNPs) (rs6433993, rs409238, rs288324, and rs4666865) spanning the entire FRZB gene. The SNPs rs288326 and rs7775, which are associated with hip osteoarthritis, were not selected in this study because of their low minor allele frequencies (MAFs) in Chinese people. The quantitative transmission disequilibrium test (QTDT) was used to analyze the association between each SNP and haplotype with peak BMD in female- and male-offspring nuclear families.In the female-offspring nuclear families, we found no evidence of an association between either single SNPs or haplotypes and peak BMD in the spine or hip. In the male-offspring nuclear families, no within-family association was observed for either SNPs or haplotypes, although a significant total association was found between rs4666865 and spine BMD (P = 0.0299).Our results suggest that natural variation in FRZB is not a major contributor to the observed variability in peak BMD in either Chinese females or males. Because ethnic differences in the FRZB genotypes may exist, other studies in different population are required to confirm such results.Osteoporosis is a skeletal disorder characterized by fragile bones susceptible to low trauma fractures. One of the most important determinants for osteoporotic fracture is low bone mineral density (BMD) [1,2], which is under strong genetic control, with heritability estimates ranging from 50% to 80% [3-5]. Osteoporosis is associated with peak bone mass achieved during early adulthood and the rate of bone loss later in life. Identification of genes underlying peak BMD may be useful in predicting the risk of low bone mass and osteoporosis in later life.The Wnt/beta-catenin signaling pathway plays an important role in skeletal development and growth [6,7]. In this pathway, Wnt signaling is transmi
%U http://www.biomedcentral.com/1471-2350/11/1