%0 Journal Article
%T Golimumab and certolizumab: The two new anti-tumor necrosis factor kids on the block
%A Mittal Mohit
%A Raychaudhuri Siba
%J Indian Journal of Dermatology, Venereology and Leprology
%D 2010
%I Medknow Publications
%X Anti-tumor necrosis factor (anti-TNF) agents have revolutionized treatment of psoriasis and many other inflammatory diseases of autoimmune origin. They have considerable advantages over the existing immunomodulators. Anti-TNF agents are designed to target a very specific component of the immune-mediated inflammatory cascades. Thus, they have lower risks of systemic side-effects. In a brief period of 10 years, a growing number of biological therapies are entering the clinical arena while many more biologicals remain on the horizon. With time, the long-term side-effects and efficacies of these individual agents will become clearer and help to determine which ones are the most suitable for long-term care. Golimumab (a human monoclonal anti-TNF-¦Á antibody) and Certolizumab (a PEGylated Fab fragment of humanized monoclonal TNF-¦Á antibody) are the two latest additions to the anti-TNF regimen. Here, we are providing a brief description about these two drugs and their uses.
%K Anti-tumor necrosis factor agents
%K Certolizumab
%K Golimumab
%U http://www.ijdvl.com/article.asp?issn=0378-6323;year=2010;volume=76;issue=6;spage=602;epage=609;aulast=Mittal