%0 Journal Article %T Knowledge loss of medical students on first year basic science courses at the university of Saskatchewan %A Marcel F D'Eon %J BMC Medical Education %D 2006 %I BioMed Central %R 10.1186/1472-6920-6-5 %X This study replicates previous memory decrement studies with three first year medicine basic science courses, something that was not found in the literature. It was expected that some courses would show more and some courses would show less knowledge loss.In the spring of 2004 over 20 students were recruited to retake questions from three first year courses: Immunology, physiology, and neuroanatomy. Student scores on the selected questions at the time of the final examination in May 2003 (the 'test') were compared with their scores on the questions 10 or 11 months later (the 're-test') using paired samples t -tests. A repeated-measures MANOVA was used to compare the test and re-test scores among the three courses. The re-test scores were matched with the overall student ratings of the courses and the student scores on the May 2003 examinations.A statistically significant main effect of knowledge loss (F = 297.385; p < .001) and an interaction effect by course (F = 46.081; p < .001) were found. The students' scores in the Immunology course dropped 13.1%, 46.5% in Neuroanatomy, and 16.1% in physiology. Bonferroni post hoc comparisons showed a significant difference between Neuroanatomy and Physiology (mean difference of 10.7, p = .004).There was considerable knowledge loss among medical students in the three basic science courses tested and this loss was not uniform across courses. Knowledge loss does not seem to be related to the marks on the final examination or the assessment of course quality by the students.With all the time and money spent teaching medical students one must wonder how well that investment is paying off. What portion are they retaining in memory? What are they learning? ¨C This seems to be the central question for medical education [1]. Surely if students are not remembering what they have been taught then the effort was wasted; if students cannot make use of the knowledge they have been taught, if that knowledge becomes inert and inaccessible, th %U http://www.biomedcentral.com/1472-6920/6/5