%0 Journal Article
%T Modelo de hemodiluci車n normovol谷mica extrema en porcinos conscientes para evaluar soluciones de reanimaci車n/ A Model of Extreme Normovolemic Hemodilution in the Conscious Swine to evaluate Resuscitation Fluids
%A Juan David P谷rez Coronado
%A Sergio David Galvis Forero
%A Andrew Akbar Shal芍 V芍squez
%A Jaime Ram車n Cabrales Ar谷valo
%J Revista de Ingenier赤a
%D 2012
%I Universidad de los Andes
%X Se desarroll車 un modelo de hemodiluci車n normovol谷mica extrema (HNE) en porcinos conscientes con 4 niveles de intercambio de sangre hasta un hematocrito <6%. En cada nivel se extrajo 40% de la volemia y se reemplaz車 con igual volumen con almid車n hidroxiet赤lico. Se encontr車 hipoxia tisular con hemoglobina (Hb) <3g/dl a las 2 horas despu谷s, luego del 迆ltimo intercambio. Sobrevivieron 4 de 10 porcinos. Solo la Hb present車 diferencia estad赤sticamente significativa luego de la instrumentaci車n con Hb <10.4 g/dl en los porcinos no sobrevivientes. Durante la HNE se encontr車 aumento de frecuencia card赤aca y gasto card赤aco, presi車n arterial divergente, aporte de ox赤geno y resistencia vascular sist谷mica disminuida.A model of ENH (Extreme Normovolemic Hemodilution) in the conscious swine was developed. A 4 level blood exchange was performed down to 6% hematocrit. In each level 40% of total blood volume was withdrawn and replaced with the same volume of hydroxyethyl starch. Below hemoglobin (Hb) 3g/dl and 2 hours after last exchange there was tissue hypoxia. 4 of 10 animals survived and only Hb after instrumentation had statistical difference with Hb <10.4 g/dl in non-surviving animals. During ENH there was tissue hypoxia, increase heart rateand cardiac output, divergent blood pressure, decrease oxygen delivery and systemic vascular resistance.
%K Modelo experimental
%K porcino
%K consciente
%K hemodiluci車n normovol谷mica
%K perfluorocarbono
%K hemosustituto./ Experimental model
%K swine
%K conscious
%K normovolemic hemodilution
%K normovelemic
%K perfluorocarbon
%K hemosubstitute.
%U https://revistaing.uniandes.edu.co/index.php?idr=51&ids=39&ida=637