%0 Journal Article
%T Molecular oncogenesis from a microRNA perspective
%A Kimberly Fan Gao
%J University of Toronto Journal of Undergraduate Life Sciences
%D 2009
%I University of Toronto
%X MicroRNAs (miRNAs) are a class of small, non-protein-coding RNA molecules that negatively regulate gene expression primarily through post-transcriptional repression. They have been implicated in the regulation of a variety of fundamental cellular and physiological processes relevant to cancer development. By acting as oncogenes ('oncomirs') or tumour suppressors, miRNAs play a crucial role in oncogenesis and cellular transformation. This review highlights the association of miRNAs with a number of cancer types and their mode of action, where available, will also be discussed.
%K apoptosis
%K cancer
%K miRNA
%K oncogenesis
%K translational repression
%U http://juls.library.utoronto.ca/index.php/juls/article/view/11148