%0 Journal Article
%T Immunohaematological reference values for HIV-negative healthy adults in Botswana
%A Madisa Mine
%A Sikhulile Moyo
%A Penny Stevens
%A Kurt Michael
%J African Journal of Laboratory Medicine
%D 2011
%I AOSIS OpenJournals
%R 10.4102/ajlm.v1i1.5
%X Background: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers＊ kits and textbooks. Objectives: The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana. Method: A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured. Results: The mean age was 28.8 (95% Confidence Interval [CI] 27.7每29.8) years, with a median of 27 years and a range 18每66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% 每 12.7%) than men (15.1 g/dL; 95% CI 14.9% 每 15.3%). The women＊s haemoglobin reference values (9.0 g/dL 每 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL 每 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL 每 15.8 g/dL) recently defined for East and Southern Africa. Conclusion: The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally.
%K Botswana
%K HIV-negative
%K Immunohaematology
%K reference intervals
%K T-lymphocytes
%U http://www.ajlmonline.org/index.php/ajlm/article/view/5