%0 Journal Article
%T Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
%A Jonna L Grimsby
%A Bianca C Porneala
%A Jason L Vassy
%A Quanhe Yang
%A Jos¨¦ C Florez
%A Jos¨¦e Dupuis
%A Tiebin Liu
%A Ajay Yesupriya
%A Man-Huei Chang
%A Renee M Ned
%A Nicole F Dowling
%A Muin J Khoury
%A James B Meigs
%A The MAGIC Investigators
%J BMC Medical Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2350-13-30
%X We studied 3,041 non-diabetic individuals in the NHANES (National Health and Nutrition Examination Survey) III. We stratified the analysis by race/ethnicity (NHW: non-Hispanic white; NHB: non-Hispanic black; MA: Mexican American) to calculate RAF, calculated a genotype score by adding risk SNPs, and tested associations with SNPs and the genotype score using an additive genetic model, with type 1 error£¿=£¿0.05.RAFs varied widely and at six loci race-ethnic differences in RAF were significant (p£¿<£¿0.0002), with NHB usually the most divergent. For instance, at ATP11A, the SNP RAF was 54% in NHB, 18% in MA and 14% in NHW (p£¿<£¿.0001). The mean genotype score differed by race-ethnicity (NHW: 10.4, NHB: 11.0, MA: 10.7, p£¿<£¿.0001), and was associated with increase in HbA1c in NHW (¦Â£¿=£¿0.012 HbA1c increase per risk allele, p£¿=£¿0.04) and MA (¦Â£¿=£¿0.021, p£¿=£¿0.005) but not NHB (¦Â£¿=£¿0.007, p£¿=£¿0.39). The genotype score was not associated with mortality in any group (NHW: OR (per risk allele increase in mortality)£¿=£¿1.07, p£¿=£¿0.09; NHB: OR£¿=£¿1.04, p£¿=£¿0.39; MA: OR£¿=£¿1.03, p£¿=£¿0.71).At many HbA1c loci in NHANES III there is substantial RAF race-ethnic heterogeneity. The combined impact of common HbA1c-associated variants on HbA1c levels varied by race-ethnicity, but did not influence mortality.
%U http://www.biomedcentral.com/1471-2350/13/30/abstract